he UK's coronavirus death toll has jumped by 143, the highest daily rise since June.
The latest fatalities within 28 days of a positive Covid-19 test, reported over the past 24 hours, take the total to 43,018.
The Department of Health confirmed there had been a further 17,234 lab-confirmed cases of coronavirus in the UK as of 9am on Tuesday.
It brings the total number of cases in the UK to 634,920.
The latest hike in the Covid-19 death toll is the highest since June 10, when 164 were reported, according to Government figures.
It comes as Boris Johnson imposes a three-tier lockdown system, seeing closures of hospitality and leisure venues and household mixing bans in hotspots.
Some 1.6 million people in Liverpool city region will become the first to be hit with new curbs in the "very high" tier three on Wednesday, while millions more will be told to avoid mixing with other households indoors under tier two.
Labour leader Sir Keir Starmer demanded an immediate two to three week "circuit break" national lockdown on Tuesday evening, accusing Boris Johnson of having "lost control of the virus" and "no longer following scientific advice".
Of the latest Covid-19 related deaths, 87 were in England hospitals bringing the total hospital toll to 30,594, NHS England said.
Patients were aged between 30 and 96 years old. All but six patients, aged between 72 and 86, had known underlying health conditions. The deaths were between October 6 and October 12. Most were on or after October 10.
Separate figures show there were 3,905 Covid-19 patients in hospital in England as of Tuesday, up from 2,783 a week ago.
Some 441 Covid-19 hospital patients were in ventilation beds, up from 349 a week ago.
A total of 628 patients with confirmed Covid-19 were admitted to hospitals in England on Sunday, the latest daily figure available, compared with 478 a week earlier.
Nightingale field hospitals in Manchester, Sunderland and Harrogate have been placed on standby.
Public Health England (PHE) said the rising number of Covid-19 deaths is “concerning”.
Dr Yvonne Doyle, PHE medical director, said: “The trend in Covid-related deaths is starting to rise quickly, which is hugely concerning.
“We have seen cases increasing especially in older age groups which is leading to more hospital admissions.
“This is a stark reminder for us to follow the guidelines. Importantly, do not mix with others when unwell.
“We must all do our part to help control the virus by following the restrictions in our areas, maintaining social distance, wearing a face covering in enclosed spaces and washing our hands regularly.”
Earlier Communities Secretary Robert Jenrick today said the Government may need to "go further" to control the spread of coronavirus, warning we will be living with coronavirus "for a long time to come".
It came as Sage, the Government's scientific advisory group, urged Boris Johnson three weeks ago to impose a "circuit-breaker" two-week lockdown, and chief medical officer Chris Whitty warned “significantly” deeper restrictions could be on their way.